The potential long-term psychological effects of DMT (dimethyltryptamine) use are complex and can vary significantly among individuals. While some users report therapeutic benefits, there are notable risks associated with its use.
Positive Psychological Effects
- Therapeutic Outcomes: Some studies, such as one by Davis et al. (2020), suggest that DMT may help alleviate symptoms of depression, anxiety, and PTSD, particularly when integrated with psychotherapy1. Users have reported enhanced creativity and increased awareness following experiences with the substance1.
Negative Psychological Effects
- Persistent Psychosis: One of the most concerning long-term effects is the potential development of persistent psychosis, which can manifest as disordered mood, paranoia, and visual disturbances23. This risk appears to be heightened in individuals with preexisting mental health conditions14.
- Hallucinogen Persisting Perception Disorder (HPPD): Users may experience HPPD, characterized by ongoing visual disturbances and hallucinations long after the drug has been taken. This condition can lead to significant distress and impairment in daily functioning23.
- Flashbacks: Some individuals report experiencing flashbacks or reoccurring trips, where they relive aspects of their DMT experiences spontaneously23. These episodes can be distressing and may interfere with normal life.
- Mood Changes: Chronic DMT use has been linked to alterations in mood, including increased anxiety and depression. These changes can adversely affect an individual’s quality of life over time14.
Cognitive and Perceptual Changes
- Altered Cognition: Long-term users may experience changes in memory and perception. Anecdotal evidence suggests that some individuals struggle to distinguish between reality and hallucinations after prolonged use14.
- Neurobiological Impact: Research indicates that DMT affects brain regions involved in mood and cognition, potentially leading to lasting changes in brain function and structure14.
Conclusion
While DMT may offer therapeutic benefits for some, its long-term psychological effects can be serious and varied. Individuals considering its use should approach it cautiously, ideally under professional guidance, especially if they have a history of mental health issues. Further research is necessary to better understand these effects and the mechanisms behind them.
